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KMID : 0604520090350020125
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Journal of the Society of Cosmetic Scientists of Korea
2009 Volume.35 No. 2 p.125 ~ p.134
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Antioxidant Activity and Component Analysis of Fermented Lavandula angustifolia Extracts
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Ahn You-Jin
Kim Jae-Hyun
Kang Myung-Kyu
Park Soo-Nam
Won Bo-Ryoung
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Abstract
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In this study, the antioxidative effects, inhibitory effects on tyrosinase, and component of non-fermented and fermented Lavandula angustifolia extracts were investigated. The ethyl acetate fraction of fermented extract (5.95 μg/mL) showed the most prominent the free radical (1,1-diphenyl-2-picrylhydrazyl, DPPH) scavenging activity (FSC50). Reactive oxygen species (ROS) scavenging activities (OSC50) of L. angustifolia extracts on ROS generated in Fe3+-EDTA/H2O2 system were investigated using the luminol-dependent chemiluminescence assay. The ethyl acetate fraction of fermented extract (1.45 μg/mL) showed the most prominent ROS scavenging activity. The protective effects of extract/fractions of L. angustifolia on the rose-bengal sensitized photohemolysis of human erythrocytes were investigated. The L. angustifolia extracts suppressed photohemolysis in a concentration dependent manner (1 ∼ 50 μg/mL). The inhibitory effect of L. angustifolia extracts on tyrosinase was investigated to assess their whitening efficacy. Inhibitory effects (IC50) on tyrosinase were determined with ethyl acetate fraction of L. angustifolia extract (144.80 μg/mL) and ethyl acetate fraction of fermented extract (122.40 μg/mL). Fractions of ethyl acetate and fermented extracts showed both 3 band in TLC and 3 peaks, 2 peaks in HPLC (340 nm), respectively. In each chromatography, fractions of ethyl acetate both from non-fermented and fermented L. angusfifolia have rosmarinic acid in common. These results indicate that the component and content of non-fermented and fermented extracts of L. angustifolia are different. Both of the extract of L. angustifolia can be used as an antioxidant.
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KEYWORD
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Lavandula angustifolia, antioxidative activity, fermented, rosmarinic acid, cosmetics
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